FEATURES

FAMILY

DESCRIPTION

Also known as RAB18_HUMAN, RAB18. Required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts (PubMed:30970241). Plays a role in apical endocytosis/recycling (By similarity). Plays a key role in eye and brain development and neurodegeneration (PubMed:21473985). Interacts (in GTP-bound form) with ZFYVE1 (PubMed:31293035, PubMed:30970241). Interacts with ZW10 and this interaction is enhanced in the presence of ZFYVE1 (PubMed:30970241). Interacts with BSCL2 (PubMed:30970241).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

RAB18

Ras-related protein Rab-18

RAB18

Molecular Synopsis