FEATURES

DESCRIPTION

Also known as FANCF_HUMAN, FANCF. DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity). Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. In complex with FANCA, FANCG and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FANCF

Fanconi anemia group F protein

FANCF

Molecular Synopsis