FEATURES

FAMILY

DESCRIPTION

Also known as ITM2C_HUMAN, ITM2C, BRI3. Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). Interacts with BACE1. Interacts with APP. Interacts with STMN2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ITM2C

Integral membrane protein 2C

ITM2C

Molecular Synopsis