FEATURES

FAMILY

DESCRIPTION

Also known as TYW1_HUMAN, TYW1, RSAFD1. Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TYW1

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

TYW1

Molecular Synopsis