FEATURES

FAMILY

DESCRIPTION

Also known as NUDT4_HUMAN, NUDT4, DIPP2, KIAA0487. Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568, PubMed:12370170). Can also catalyze the hydrolysis of diadenosine 5', 5'''-P1, P6-hexaphosphate (Ap6A) but not diadenosine 5', 5'''-P1, P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (PubMed:12370170). Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity).

EXTERNAL LINKS

NUDT4

Diphosphoinositol polyphosphate phosphohydrolase 2

NUDT4

Molecular Synopsis