FEATURES

DESCRIPTION

Also known as WDR35_HUMAN, WDR35, IFT121, KIAA1336. As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (PubMed:21473986, PubMed:28400947, PubMed:29220510). May promote CASP3 activation and TNF-stimulated apoptosis. Component of the IFT complex A (IFT-A) complex (PubMed:20889716, PubMed:27932497, PubMed:29220510). IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B (PubMed:27932497, PubMed:29220510). Interacts directy with IFT122, ITF43 and TTC21B (PubMed:29220510, PubMed:27932497). Interacts with IFT43 (PubMed:19450523).

EXTERNAL LINKS

WDR35

WD repeat-containing protein 35

WDR35

Molecular Synopsis