FEATURES

DESCRIPTION

Also known as HECW2_HUMAN, HECW2, KIAA1301, NEDL2. E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370). Interacts with TP73 (PubMed:12890487). Interacts with FZR1 (PubMed:24163370).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HECW2

E3 ubiquitin-protein ligase HECW2

HECW2

Molecular Synopsis