FEATURES

FAMILY

succinate/malate CoA ligase beta subunit family

DESCRIPTION

Also known as SUCB1_HUMAN, SUCLA2. ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA (PubMed:15877282). The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit (By similarity). Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP (By similarity). Interacts with ALAS2 (PubMed:14643893).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SUCLA2

Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

SUCLA2

Molecular Synopsis