FEATURES

FAMILY

DESCRIPTION

Also known as KCNN3_HUMAN, KCNN3, K3. Forms a voltage-independent potassium channel activated by intracellular calcium (PubMed:31155282, PubMed:20562108). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity). Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity). Interacts with CALM1 (PubMed:31155282).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KCNN3

Small conductance calcium-activated potassium channel protein 3

KCNN3

Molecular Synopsis