FEATURES

FAMILY

eukaryotic-type N-acetylglucosamine kinase family

DESCRIPTION

Also known as NAGK_HUMAN, NAGK. Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NAGK

N-acetyl-D-glucosamine kinase

NAGK

Molecular Synopsis