FEATURES

DESCRIPTION

Also known as GMEB2_HUMAN, GMEB2, KIAA1269. Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses. Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1). May interact with CREB-binding protein (CBP).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GMEB2

Glucocorticoid modulatory element-binding protein 2

GMEB2

Molecular Synopsis