FEATURES

FAMILY

DESCRIPTION

Also known as TLK1_HUMAN, TLK1, KIAA0137. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. Heterodimerizes with TLK2. Interacts with ASF1A and ASF1B.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TLK1

Serine/threonine-protein kinase tousled-like 1

TLK1

Molecular Synopsis