FEATURES

DESCRIPTION

Also known as PKCB1_HUMAN, ZMYND8, KIAA1125, PRKCBP1, RACK7. May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion. Interacts in vitro with PRKCB1 (PubMed:11003709). Interacts with KDM5D and KDM1A (PubMed:27477906). Interacts with histone H3 (via N-terminus) that is both methylated at 'Lys-4' (H3K4me1) and acetylated at 'Lys-14' (H3K14ac), and with histone H3 (via N-terminus) unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-14' (H3K14ac) (PubMed:27477906). Interacts (via PHD-type Zinc finger, Bromo and PWWP domains) with DBN1 (via ADF-H domain); the interaction leads to sequestering of ZMYND8 in the cytoplasm (PubMed:28966017).

EXTERNAL LINKS

ZMYND8

Protein kinase C-binding protein 1

ZMYND8

Molecular Synopsis