FEATURES

FAMILY

Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family

DESCRIPTION

Also known as NAC2_HUMAN, SLC8A2, KIAA1087, NCX2. Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC8A2

Sodium/calcium exchanger 2

SLC8A2

Molecular Synopsis