FEATURES

FAMILY

DESCRIPTION

Also known as CD11A_HUMAN, CDK11A, CDC2L2, CDC2L3, PITSLREB. Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7.

Also known as CD11A_HUMAN, CDK11A, CDC2L2, CDC2L3, PITSLREB. Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be invol ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CDK11A

Cyclin-dependent kinase 11A

CDK11A

Molecular Synopsis