FEATURES

FAMILY

DESCRIPTION

Also known as ENTP4_HUMAN, ENTPD4, KIAA0392, LALP70, LYSAL1. Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP. AMP, ADP, ATP and UMP are not substrates (PubMed:10858452, PubMed:9556635). Preferentially activated by Ca(2+) over Mg(2+) (PubMed:10858452)., Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally.

Also known as ENTP4_HUMAN, ENTPD4, KIAA0392, LALP70, LYSAL1. Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference f ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ENTPD4

Ectonucleoside triphosphate diphosphohydrolase 4

ENTPD4

Molecular Synopsis