FEATURES

DESCRIPTION

Also known as AXIN2_HUMAN, AXIN2. Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

AXIN2

Axin-2

AXIN2

Molecular Synopsis