FEATURES

FAMILY

DESCRIPTION

Also known as M3K2_HUMAN, MAP3K2, MAPKKK2, MEKK2. Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. Interacts with PKN2; the interaction activates PKN2 kinase activity in a MAP3K2-independent kinase activity (By similarity). Self-associates. Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts (via the kinase catalytic domain) with STK38. Interacts with XIAP/BIRC4.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MAP3K2

Mitogen-activated protein kinase kinase kinase 2

MAP3K2

Molecular Synopsis