FEATURES

FAMILY

DESCRIPTION

Also known as NR2E1_HUMAN, NR2E1, TLX. Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. Monomer. Interacts with ATN1; the interaction represses the transcription.

EXTERNAL LINKS

NR2E1

Nuclear receptor subfamily 2 group E member 1

NR2E1

Molecular Synopsis