FEATURES

DESCRIPTION

Also known as NOX1_HUMAN, NOX1, MOX1, NOH1. NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting reactive oxygen species (ROS) production. Interacts with NOXA1 and NOXO1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NOX1

NADPH oxidase 1

NOX1

Molecular Synopsis