FEATURES

FAMILY

DESCRIPTION

Also known as CAN6_HUMAN, CAPN6, CALPM, CANPX. Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CAPN6

Calpain-6

CAPN6

Molecular Synopsis